In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Parkinson disease (PD) is a progressive neurodegenerative disease (NDD) of the brain. It
has been reported that prolactin (PRL) hormone plays a differential effect in PD, may be …

The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mt DNA)‐binding
protein essential for genome maintenance. TFAM functions in determining the abundance of …

Background Memantine, drug approved for moderate to severe Alzheimer's disease, has not
shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) …

Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an
accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have …

Metformin is used for the treatment of insulin resistant diabetes. Diabetics are at an
increased risk of developing dementia. Recent epidemiological studies suggest that …

Amyloid plaques in Alzheimer's disease (AD) mice are surrounded by activated microglia.
The functional role of microglia activation in AD is not well understood; both detrimental and …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …