Abstract Adenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that
play a dynamic and nuanced role in regulating transcriptome and proteome diversity. This …

Pangolins are endangered animals in urgent need of protection. Identifying and cataloguing
the viruses carried by pangolins is a logical approach to evaluate the range of potential …

Simple Summary Even though it is known that (cancer) cells can fuse, it is still less
understood how (cancer) cells merge their plasma membranes, thereby giving rise to bi-and …

Necroptosis is a form of necrotic cell death that requires the activity of the death domain-
containing kinase RIP1 and its family member RIP3. Necroptosis occurs when RIP1 is …

CTLs and NK cells use the perforin/granzyme cytotoxic pathway to kill virally infected cells
and tumors. Human regulatory T cells also express functional granzymes and perforin and …

Otitis media is an inflammatory disorder of the middle ear caused by airways-associated
bacterial or viral infections. It is one of the most common childhood infections as globally …

Abstract Background Flaviviruses such as Zika cause sporadic pandemic outbreaks
worldwide. There is an urgent need for anti-Zika virus (ZIKV) drugs to prevent mother-to …

The paramyxoviridae, respiratory syncytial virus (RSV), and murine respirovirus are
enveloped, negative-sense RNA viruses that are the etiological agents of vertebrate lower …

Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with
alarming frequency. The molecular underpinnings of immune recognition, host responses …

To design an effective and safe vaccine against betacoronaviruses, it is necessary to use
their evolutionarily conservative antigenic determinants that will elicit the combination of …