[HTML][HTML] Normal and glaucomatous outflow regulation

TS Acott, JA Vranka, KE Keller, VK Raghunathan… - Progress in retinal and …, 2021 - Elsevier
Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

Newer advances in medical management of glaucoma

N Mohan, A Chakrabarti, N Nazm… - Indian journal of …, 2022 - journals.lww.com
The burden of irreversible vision loss from Glaucoma continues to rise. While the disease
pathogenesis is not well understood, intraocular pressure (IOP) is the only modifiable risk …

Long non‐coding RNA SNHG11 regulates the Wnt/β‐catenin signaling pathway through rho/ROCK in trabecular meshwork cells

L Liu, X Yang, J Zhang, W Jiang, T Hou… - The FASEB …, 2023 - Wiley Online Library
Trabecular meshwork (TM) cell dysfunction is the leading cause of elevated intraocular
pressure (IOP) and glaucoma. The long non‐coding RNA (lncRNA) small nucleolar RNA …

[HTML][HTML] Glaucoma: Current and New Therapeutic Approaches

HP Lee, TH Tsung, YC Tsai, YH Chen, DW Lu - Biomedicines, 2024 - mdpi.com
Glaucoma is identified by the loss of retinal ganglion cells (RGCs). The primary approach to
managing glaucoma is to control intraocular pressure (IOP). Lately, there has been an …

Suppression of TGF-β1 signaling by Matrigel via FAK signaling in cultured human trabecular meshwork cells

Y Zhang, SCG Tseng, YT Zhu - Scientific Reports, 2021 - nature.com
The trabecular meshwork (TM) is composed of TM cells and beams of the extracellular
matrix, together contributing to aqueous humor (AH) outflow resistance. Herein, we validated …

[HTML][HTML] mTOR Inhibitors Modulate the Biological Nature of TGF-β2-Treated or-Untreated Human Trabecular Meshwork Cells in Different Manners

M Watanabe, T Sato, T Yano, M Higashide, T Ogawa… - Biomedicines, 2024 - mdpi.com
Background/Objectives: Mammalian target of rapamycin (mTOR) inhibition may have been
suggested to have a beneficial effect on the glaucomatous human trabecular meshwork …

Development of Cell Culture Platforms for Study of Trabecular Meshwork Cells and Glaucoma Development

KI Youn, JW Lee, Y Song, SY Lee, KH Song - Tissue Engineering and …, 2024 - Springer
Background: Various cell culture platforms that could display native environmental cue-
mimicking stimuli were developed, and effects of environmental cues on cell behaviors were …

Ferroptosis in Glaucoma: A Promising Avenue for Therapy

J Zhu, H Chen, J Wu, S Li, W Lin, N Wang… - Advanced …, 2024 - Wiley Online Library
Glaucoma, a blind‐leading disease largely since chronic pathological intraocular high
pressure (ph‐IOP). Hitherto, it is reckoned incurable for irreversible neural damage and …

All-trans Retinoic Acids Synergistically and Beneficially Affect In Vitro Glaucomatous Trabecular Meshwork (TM) Models Using 2D and 3D Cell Cultures of Human TM …

M Watanabe, T Sato, Y Tsugeno, M Higashide… - International Journal of …, 2022 - mdpi.com
We report herein on the effects of all-trans retinoic acid (ATRA) on two-dimensional (2D) and
three-dimensional (3D) cultures of human trabecular meshwork (HTM) cells that were …

[PDF][PDF] The effect of anabasis articulata stems extract on lowering intraocular pressure in the glaucoma rat model (conference paper)

WK Abdulsahib - Iraqi Journal of Pharmaceutical Sciences (P-ISSN 1683 …, 2021 - iasj.net
High intraocular pressure (IOP) is a recognized risk factor for glaucoma and optic nerve
injury, and it is one of the primary causes of vision loss globally. Anabasis articulata (AA) is a …