Immunologically active components in human milk and development of atopic disease, with emphasis on food allergy, in the pediatric population

PS Rajani, AE Seppo, KM Järvinen - Frontiers in pediatrics, 2018 - frontiersin.org
Breast-feeding is currently recommended to prevent the development of allergic diseases;
however, data are conflicting and mechanisms are unclear. The immunomodulatory …

Infant gut microbiome is enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites with traditional farming lifestyle

AE Seppo, K Bu, M Jumabaeva, J Thakar… - Allergy, 2021 - Wiley Online Library
Background Growing up on traditional, single‐family farms is associated with protection
against asthma in school age, but the mechanisms against early manifestations of atopic …

Environmental exposures may hold the key; impact of air pollution, greenness, and rural/farm lifestyle on allergic outcomes

CM Jackson, AN Kaplan, KM Järvinen - Current allergy and asthma reports, 2023 - Springer
Abstract Purpose of Review There has been an increased prevalence of allergy. Due to this
relatively rapid rise, changes in environmental exposures are likely the main contributor. In …

Phthalate exposure in Chinese homes and its association with household consumer products

Q Zhang, Y Sun, Q Zhang, J Hou, P Wang… - Science of the Total …, 2020 - Elsevier
Abstract Phthalates are SVOCs (Semi-volatile Organic Compounds) that are widely used in
industrial and daily home products. This study aimed to investigate exposure levels to …

Halting the march: primary prevention of atopic dermatitis and food allergies

F Bawany, LA Beck, KM Järvinen - The Journal of Allergy and Clinical …, 2020 - Elsevier
Atopic dermatitis (AD) is one of the most common inflammatory skin conditions, affecting
15% to 30% of children and 2% to 10% of adults. Population-based studies suggest that …

Modern life makes children allergic. A cross-sectional study: associations of home environment and lifestyles with asthma and allergy among children in Tianjin region …

Y Sun, J Hou, Y Sheng, X Kong, LB Weschler… - International archives of …, 2019 - Springer
Purpose In the past 60 years, the prevalences of asthma and allergy among children have
increased around the world. Neither genetic nor outdoor environmental factors can explain …

Traditional farming lifestyle in old older mennonites modulates human milk composition

AE Seppo, R Choudhury, C Pizzarello, R Palli… - Frontiers in …, 2021 - frontiersin.org
Background In addition to farming exposures in childhood, maternal farming exposures
provide strong protection against allergic disease in their children; however, the effect of …

Quantitative glycoproteomics of human milk and association with atopic disease

M Holm, M Saraswat, S Joenväärä, A Seppo… - PLoS …, 2022 - journals.plos.org
The prevalence of allergic diseases and asthma is increasing rapidly worldwide, with
environmental and lifestyle behaviors implicated as a reason. Epidemiological studies have …

Food allergy, breastfeeding, and introduction of complementary foods in the New York Old Order Mennonite Community

JT Phillips, RW Stahlhut, RJ Looney… - Annals of Allergy …, 2020 - annallergy.org
The prevalence of allergic diseases and asthma has been increasing in developed
countries for the past 50 years, likely associated with changes in living conditions that have …

Variations in human milk composition: impact on immune development and allergic disease susceptibility

KM Järvinen - Breastfeeding Medicine, 2018 - liebertpub.com
Food allergy affects 6–8% of children and is the leading cause of anaphylaxis.
Approximately 30–40% of children with moderate-to-severe eczema also have food …