The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

Loss of functionality during aging of cells and organisms is caused and accompanied by
altered cell-to-cell communication and signalling. One factor thereby is the chronic …

The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Background Tumor-associated macrophages (TAM) play an important role in tumor
microenvironment. Particularly, M2 macrophages contribute to tumor progression …

Cellular and viral microRNAs (miRNAs) are the transcriptional products of RNA polymerase
II and are regulated by transcriptional factors for their differential expression. The altered …

Analyses of the international human genome sequencing results in 2004 converged to a
consensual number of~ 20 000 protein‐coding genes, spanning over< 2% of the total …

Background JUNB transcription factor contributes to the formation of the ubiquitous
transcriptional complex AP-1 involved in the control of many physiological and disease …

The fallopian tube is now generally considered the dominant site of origin for high-grade
serous ovarian carcinoma. However, the molecular pathogenesis of fallopian tube-derived …