Apolipoprotein (apo) B, the critical structural protein of the atherogenic lipoproteins, has two
major isoforms: apoB48 and apoB100. ApoB48 is found in chylomicrons and chylomicron …

Type 2 diabetes mellitus is an important preventable disease and a growing public health
problem. Epidemiologic and interventional studies suggest that weight loss is the main …

Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic
hyperglycemia either immune-mediated (Type 1 diabetes), insulin resistance (Type 2) …

Aims/hypothesis Metabolomics technologies have identified numerous blood biomarkers for
type 2 diabetes risk in case− control studies of middle-aged and older individuals. We aimed …

OBJECTIVE The inflammatory and immune systems are altered in type 2 diabetes. Here, the
aim was to profile the immune and inflammatory response in subjects with prediabetes and …

OBJECTIVE Diabetes is accompanied with a chronic low-grade inflammation, which may in
part be mediated by endotoxins derived from Gram-negative bacteria. RESEARCH DESIGN …

Key Clinical Points Diagnosis of Diabetes Early screening and diagnosis allow for the
identification of at-risk persons (so that preventive measures, primarily lifestyle changes …

Background: Demographic differences in expected NT-proBNP (N-terminal pro-B-type
natriuretic peptide) concentration are not well established. We aimed to establish reference …

Comprehensive characterization of human tissues promises novel insights into the
biological architecture of human diseases and traits. We assessed metabonomic …

Iron is an essential element for several metabolic pathways and physiological processes.
The maintenance of iron homeostasis within the human body requires a dynamic and highly …