Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Background: Opioid overdose survivors have an increased risk for death. Whether use of
medications for opioid use disorder (MOUD) after overdose is associated with mortality is not …

Opioid use disorder is characterised by the persistent use of opioids despite the adverse
consequences of its use. The disorder is associated with a range of mental and general …

Background Extended-release naltrexone (XR-NTX), an opioid antagonist, and sublingual
buprenorphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and …

Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …

The widespread abuse of prescription opioids and a dramatic increase in the availability of
illicit opioids have created what is commonly referred to as the opioid epidemic. The …

We investigated prescribing patterns for four opioid use disorder (OUD) medications: 1)
injectable naltrexone, 2) oral naltrexone, 3) sublingual or oralmucosal buprenorphine …

Importance Health profiles and patterns of involvement in the criminal justice system among
people with various levels of opioid use are poorly defined. Data are needed to inform a …

Importance To date, extended-release naltrexone hydrochloride has not previously been
compared directly with opioid medication treatment (OMT), currently the most commonly …