Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of
macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and …

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent
adducts with the plasma proteins through a non-enzymatic process known as glycation …

Improvements in health care and lifestyle have led to an elevated lifespan and increased
focus on age-associated diseases, such as neurodegeneration, cardiovascular disease …

Despite new and effective drug therapies, insulin resistance (IR), type 2 diabetes mellitus
(T2D) and its complications remain major medical challenges. It is accepted that IR, often …

Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

The formation of advanced glycation end products (AGEs) in foods is accelerated with heat
treatment, particularly within foods that are cooked at high temperatures for long periods of …

Aging is the progressive accumulation of damage to an organism over time leading to
disease and death. Aging research has been very intensive in the last years aiming at …

Context: Diabetic complications appear to be multifactorial in origin, but in particular, the
biochemical process of advanced glycation, which is accelerated in diabetes as a result of …

Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …

Aims/hypothesis The accumulation of AGE is thought to play a role in the pathogenesis of
chronic complications of diabetes mellitus and renal failure. All current measurements of …