The past 3 decades have been characterized by an exponential growth in knowledge and
advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

SCN5A gene encodes the pore-forming ion-conducting α-subunit of the cardiac sodium
channel (Nav1. 5), which is responsible for the initiation and propagation of action potentials …

Atrial fibrillation (AF) is the most common arrhythmia with ever-increasing public health
impact. 1 Over 50 years of observation in the Framingham Heart Study (FHS), there is a 4 …

Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …

Atrial fibrillation (AF) is a significant health care problem for patients with obstructive sleep
apnea (OSA). Continuous positive airway pressure (CPAP) as a therapy for OSA is …

Nav1. 5 is the primary voltage-gated Na+ (Nav) channel in the heart. Mutations of Nav1. 5
are associated with various cardiac disorders exemplified by the type 3 long QT syndrome …

Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …

The cardiac voltage-gated Na+ channel Nav1. 5 generates the cardiac Na+ current (INa).
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …