Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …

Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that …

Aims Atherosclerotic cardiovascular disease (ACVD) is a major cause of mortality and
morbidity worldwide, and increased low-density lipoproteins (LDLs) play a critical role in …

In addition to their classical roles as detergents to aid in the process of digestion, bile acids
have been identified as important signaling molecules that function through various nuclear …

The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

The liver can substantially regenerate after injury, with both main epithelial cell types,
hepatocytes and biliary epithelial cells (BECs), playing important roles in parenchymal …

Bile acids are physiological detergents that generate bile flow and facilitate intestinal
absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

Gut microbiota influences host health status by providing trophic, protective, and metabolic
functions, including bile acid (BA) biotransformation. Microbial imprinting on BA signature …