Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

Metabolic reprogramming is an emerging hallmark of cancer cells, in which cancer cells
exhibit distinct metabolic phenotypes to fuel their proliferation and progression. The …

Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive.
Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells …

Mitochondria are essential cellular organelles that are involved in regulating cellular energy,
metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic …

Iron is an essential element for biological processes. Iron homeostasis is regulated through
several mechanisms, from absorption by enterocytes to recycling by macrophages and …

Most cancer-related deaths among patients with solid tumors are caused by metastases.
Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer …

One of the characteristics of cancer cells important for tumorigenesis is their metabolic
plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic …

Recent evidence highlights that the cancer cell energy requirements vary greatly from
normal cells and that cancer cells exhibit different metabolic phenotypes with variable …

Background We evaluated the therapeutic potential of combining the monocarboxylate
transporter 1 (MCT1) inhibitor AZD3965 with the mitochondrial respiratory Complex I …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …