Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

Our current alveolar paradigm includes three highly specialized cell populations. Alveolar
type I cells are flat, elongated cells that presumably enable gas exchange. Alveolar type II …

Although acute lung injury contributes significantly to critical illness, resolution often occurs
spontaneously via activation of incompletely understood pathways. We recently found that …

Metabolomics is an emerging component of systems biology that may be a viable strategy
for the identification and validation of physiologically relevant biomarkers. Nuclear magnetic …

Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and
comprehensive reference for all those involved in pulmonary research. This fully updated …

Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and
interstitial lung disease are characterized by inflammation and tissue remodeling processes …

An important determinant of disease following Streptococcus pneumoniae (pneumococcus)
lung infection is pulmonary inflammation mediated by polymorphonuclear leukocytes …

Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJs) that
regulate paracellular permeability to ions and solutes. Claudin 18, a member of the large …

Extracellular ATP controls key aspects of lung function via activation of epithelial cell
purinergic receptors, but how ATP is released from cells remains poorly understood. To …

Recent progress in our understanding of the unique role of A 2B receptors in the regulation
of inflammation, immunity, and tissue repair was considerably facilitated with the introduction …