Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9-tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …

Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …

Increasing evidence suggests that an overactive endocannabinoid system (ECS) may
contribute to the development of diabetes by promoting energy intake and storage, impairing …

G protein–coupled receptors (GPCRs) continue to be important discovery targets for the
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …

Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …

Significance: Redox imbalance may lead to overproduction of reactive oxygen and nitrogen
species (ROS/RNS) and subsequent oxidative tissue damage, which is a critical event in the …