A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and
protein expression, point to biological functions and molecular pathways being deregulated …

Pathway analysis is often the first choice for studying the mechanisms underlying a
phenotype. However, conventional methods for pathway analysis do not take into account …

Studying protein interaction networks of all proteins in an organism (“interactomes”) remains
one of the major challenges in modern biomedicine. Such information is crucial to …

Motivation: With the exponential growth of expression and protein–protein interaction (PPI)
data, the frontier of research in systems biology shifts more and more to the integrated …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Dynamic molecular interactions play a central role in regulating the functioning of cells and
organisms. The availability of experimentally determined large-scale cellular networks …

Protein–protein interactions (PPIs) participate in all important biological processes in living
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …

Cancer is a complex and heterogeneous disease that exhibits high levels of robustness
against various therapeutic interventions. It is a constellation of diverse and evolving …

Emerging evidence indicates that gene products implicated in human cancers often cluster
together in “hot spots” in protein-protein interaction (PPI) networks. Additionally, small sub …