The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating
regenerative diseases. Among many stem cells, the feasibility of using adult-derived …

Background Results of small-scale studies have suggested that stem-cell therapy is safe
and effective in patients with liver cirrhosis, but no adequately powered randomised …

Mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs) have been
extensively investigated in small animal models to treat both acute and chronic liver injuries …

Objective Impaired liver regeneration is associated with a poor outcome in patients with
decompensated alcoholic liver disease (ALD). We assessed whether autologous bone …

The advent of highly conformal radiation therapy (RT) has defined a new role for RT in the
treatment of both primary and metastatic liver cancer. Despite major advances in how RT is …

Background Stem cell therapy is becoming an emerging therapeutic option for chronic liver
disease (CLD). However, whether stem cell therapy is more effective than conventional …

Liver cirrhosis is a major cause of mortality and a common end of various progressive liver
diseases. Since the effective treatment is currently limited to liver transplantation, stem cell …

There is an increasing range of potential applications of stem cells in liver diseases, with
many clinical studies already undertaken. We identify four of the main areas which we …

Although the liver has a high regenerative capacity, as a result of massive hepatocyte death,
liver failure occurs. In addition to liver failure, for acute, chronic and hereditary diseases of …