Food components have long been recognized to play a fundamental role in the growth and
development of the human body, conferring protective functionalities against foreign matter …

Sickle cell disease (SCD) substantially alters renal structure and function, and causes
various renal syndromes and diseases. Such diverse renal outcomes reflect the uniquely …

The increase of extracellular heme is a hallmark of hemolysis or extensive cell damage.
Heme has prooxidant, cytotoxic, and inflammatory effects, playing a central role in the …

Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …

Damage associated molecular patterns (DAMPs) are endogenous molecules originate from
damaged cells and tissues with the ability to trigger and/or modify innate immune responses …

Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Iron is an essential mineral required for a variety of vital biological functions. Despite being
vital for life, iron also has potentially toxic aspects. Iron has been investigated as a risk factor …

Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging
biomarker of disease resistance, which may be related to several recently documented …

Abstract Significance: Heme oxygenase-1 (HMOX1) plays a critical role in the protection of
cells, and the inducible enzyme is implicated in a spectrum of human diseases. The …

Hemolytic diseases include a variety of conditions with diverse etiologies in which red blood
cells are destroyed and large amounts of hemeproteins are released. Heme has been …