TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
M Morikawa, R Derynck… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease
E Mogilyansky, I Rigoutsos - Cell Death & Differentiation, 2013 - nature.com
Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …
cluster and its members has been increasing steadily and the number of publications has …
TGF-β signal transduction
J Massagué - Annual review of biochemistry, 1998 - annualreviews.org
The transforming growth factor β (TGF-β) family of growth factors control the development
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …
TGF-β signalling from cell membrane to nucleus through SMAD proteins
CH Heldin, K Miyazono, P Ten Dijke - Nature, 1997 - nature.com
The recent identification of the SMAD family of signal transducer proteins has unravelled the
mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane …
mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane …
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
V Groh, J Wu, C Yee, T Spies - Nature, 2002 - nature.com
Engagement of the NKG2D receptor by tumour-associated ligands may promote tumour
rejection by stimulating innate and adaptive lymphocyte responses,,,,. In humans, NKG2D is …
rejection by stimulating innate and adaptive lymphocyte responses,,,,. In humans, NKG2D is …
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
A Nakao, M Afrakhte, A Morn, T Nakayama… - Nature, 1997 - nature.com
TGF-β signals from the membrane to the nucleus through serine/threonine kinase receptors
and their downstream effectors, termed SMAD proteins. The activated TGF-β receptor …
and their downstream effectors, termed SMAD proteins. The activated TGF-β receptor …
Non-Smad TGF-β signals
A Moustakas, CH Heldin - Journal of cell science, 2005 - journals.biologists.com
During the past 10 years, it has been firmly established that Smad pathways are central
mediators of signals from the receptors for transforming growth factor β (TGF-β) superfamily …
mediators of signals from the receptors for transforming growth factor β (TGF-β) superfamily …
Transcriptional activators of TGF-β responses: Smads
Smads are a class of proteins that function as intracellusive promoter sites. Thus, Smads
have been shown to lar signaling effectors for the TGF-ß superfamily of seact as transcription …
have been shown to lar signaling effectors for the TGF-ß superfamily of seact as transcription …
[HTML][HTML] TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses
L Yu, MC Hébert, YE Zhang - The EMBO journal, 2002 - embopress.org
Through the action of its membrane‐bound type I receptors, transforming growth factor‐β
(TGF‐β) elicits a wide range of cellular responses that regulate cell proliferation …
(TGF‐β) elicits a wide range of cellular responses that regulate cell proliferation …
TGF-β signaling by Smad proteins
K Miyazono - Cytokine & growth factor reviews, 2000 - Elsevier
Smads are signal transducers for the members of the transforming growth factor-β (TGF-β)
superfamily. Bone morphogenetic proteins (BMPs) and their receptors induce differentiation …
superfamily. Bone morphogenetic proteins (BMPs) and their receptors induce differentiation …