The therapeutic limitations such as insufficient efficacy, drug resistance, metastasis, and
undesirable side effects are frequently caused by the long duration monotherapy based on …

Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic
option for many disorders. However, poor bioavailability and selectivity might limit their …

Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried
rhizomes of Curcuma longa L.(turmeric). Curcumin is known as a strong anti-oxidant and …

Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …

Background Curcumin is the main active ingredient of the spice turmeric, investigated
extensively for putative anticancer properties. Objectives This phase IIa open-labelled …

Abstract Development of resistance to chemotherapeutic drugs is a major challenge in the
care of patients with pancreatic ductal adenocarcinoma (PDAC). Acquired resistance to …

The Notch signaling pathway is evolutionarily conserved and responsible for cell fate
determination in the developing embryo and mature tissue. At the molecular level, ligand …

Colorectal‐cancer (CRC) is the third leading cause of death due to cancer, supporting the
need for identification of novel anticancer drug to improve the efficacy of current‐therapy …

Oxaliplatin (OXA) resistance is the major obstacle to the anticancer effects of chemotherapy
in colorectal cancer (CRC) patients. MicroRNAs (miRNAs) play an important role in the …