Exosomal circRNAs: biogenesis, effect and application in human diseases

Y Wang, J Liu, J Ma, T Sun, Q Zhou, W Wang, G Wang… - Molecular cancer, 2019 - Springer
Exosomes have emerged as critical mediators of intercellular communication, both locally
and systemically, by regulating a diverse range of biological processes between cells …

Exosomes: Therapy delivery tools and biomarkers of diseases

L Barile, G Vassalli - Pharmacology & therapeutics, 2017 - Elsevier
Virtually all cells in the organism secrete extracellular vesicles (EVs), a heterogeneous
population of lipid bilayer membrane-enclosed vesicles that transport and deliver payloads …

Biological functions and current advances in isolation and detection strategies for exosome nanovesicles

K Boriachek, MN Islam, A Möller, C Salomon… - Small, 2018 - Wiley Online Library
Abstract Exosomes are nanoscale (≈ 30–150 nm) extracellular vesicles of endocytic origin
that are shed by most types of cells and circulate in bodily fluids. Exosomes carry a specific …

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

RA Haraszti, MC Didiot, E Sapp, J Leszyk… - Journal of …, 2016 - Taylor & Francis
Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), are explored for
use in diagnostics, therapeutics and drug delivery. However, little is known about the …

Exosome mediated communication within the tumor microenvironment

L Milane, A Singh, G Mattheolabakis, M Suresh… - Journal of Controlled …, 2015 - Elsevier
It is clear that exosomes (endosome derived vesicles) serve important roles in cellular
communication both locally and distally and that the exosomal process is abnormal in …

Exosomes in bodily fluids are a highly stable resource of disease biomarkers

S Boukouris, S Mathivanan - PROTEOMICS–Clinical …, 2015 - Wiley Online Library
Biomarkers are measurable indicators of a biological state. As our understanding of
diseases meliorates, it is generally accepted that early diagnosis renders the best chance to …

Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy

S Kourembanas - Annual review of physiology, 2015 - annualreviews.org
Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine,
are being widely tested for the treatment of a variety of human diseases. No one factor has …

A comprehensive overview of exosomes as drug delivery vehicles—endogenous nanocarriers for targeted cancer therapy

KB Johnsen, JM Gudbergsson, MN Skov… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Exosomes denote a class of secreted nanoparticles defined by size, surface protein and
lipid composition, and the ability to carry RNA and proteins. They are important mediators of …

The origin and functions of exosomes in cancer

C Rajagopal, KB Harikumar - Frontiers in oncology, 2018 - frontiersin.org
Exosomes are nanovesicles having a maximum size of 150 nm and is a newly emerging
focus in various fields of research. Its role in cargo trafficking along with its differential …

[HTML][HTML] Metabolomic profiling of extracellular vesicles and alternative normalization methods reveal enriched metabolites and strategies to study prostate cancer …

M Puhka, M Takatalo, ME Nordberg, S Valkonen… - Theranostics, 2017 - ncbi.nlm.nih.gov
Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from
the secreting cells. So far, biomarkers for pathological conditions have been mainly …