Elastin architecture

H Vindin, SM Mithieux, AS Weiss - Matrix biology, 2019 - Elsevier
Elastic fibers are an essential component of the extracellular matrix where they provide
structural integrity and elastic recoil in a number of important tissues. A major constituent of …

Structural disorder and dynamics of elastin

LD Muiznieks, AS Weiss… - Biochemistry and Cell …, 2010 - cdnsciencepub.com
Elastin is a self-assembling, extracellular-matrix protein that is the major provider of tissue
elasticity. Here we review structural studies of elastin from over four decades, and draw …

Tropoelastin: a versatile, bioactive assembly module

SG Wise, GC Yeo, MA Hiob, J Rnjak-Kovacina… - Acta biomaterialia, 2014 - Elsevier
Elastin provides structural integrity, biological cues and persistent elasticity to a range of
important tissues, including the vasculature and lungs. Its critical importance to normal …

Structural disorder and protein elasticity

S Rauscher, R Pomès - Fuzziness: Structural disorder in protein …, 2012 - Springer
An emerging class of disordered proteins underlies the elasticity of many biological tissues.
Elastomeric proteins are essential to the function of biological machinery as diverse as the …

Degradation of tropoelastin by matrix metalloproteinases–cleavage site specificities and release of matrikines

A Heinz, MC Jung, L Duca, W Sippl… - The FEBS …, 2010 - Wiley Online Library
To provide a basis for the development of approaches to treat elastin‐degrading diseases,
the aim of this study was to investigate the degradation of the natural substrate tropoelastin …

A review of combined experimental and computational procedures for assessing biopolymer structure–process–property relationships

G Gronau, ST Krishnaji, ME Kinahan, T Giesa… - Biomaterials, 2012 - Elsevier
Tailored biomaterials with tunable functional properties are desirable for many applications
ranging from drug delivery to regenerative medicine. To improve the predictability of …

Materiomics: biological protein materials, from nano to macro

S Cranford, MJ Buehler - Nanotechnology, science and …, 2010 - Taylor & Francis
Materiomics is an emerging field of science that provides a basis for multiscale material
system characterization, inspired in part by natural, for example, protein-based materials …

[HTML][HTML] Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin

LD Muiznieks, JT Cirulis, A van der Horst… - Matrix Biology, 2014 - Elsevier
Elastin self-assembles from monomers into polymer networks that display elasticity and
resilience. The first major step in assembly is a liquid–liquid phase separation known as …

Elastin-based biomaterials and mesenchymal stem cells

J Ozsvar, SM Mithieux, R Wang, AS Weiss - Biomaterials science, 2015 - pubs.rsc.org
Elastin is the dominant mammalian elastic protein found in soft tissue. Elastin-based
biomaterials have the potential to repair elastic tissues by improving local elasticity and …

Tropoelastin is a flexible molecule that retains its canonical shape

A Tarakanova, GC Yeo, C Baldock… - Macromolecular …, 2019 - Wiley Online Library
Tropoelastin is the dominant building block of elastic fibers, which form a major component
of the extracellular matrix, providing structural support to tissues and imbuing them with …