Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

The branching of axons is a fundamental aspect of nervous system development and
neuroplasticity. We report that branching of sensory axons in the presence of nerve growth …

Mitochondria are dynamic organelles that undergo transport, fission, and fusion. The three
main functions of mitochondria are to generate ATP, buffer cytosolic calcium, and generate …

Inhibition of histone deacetylase 6 (HDAC6) was shown to support axon growth on the
nonpermissive substrates myelin-associated glycoprotein (MAG) and chondroitin sulfate …

Maintenance of neuronal homeostasis is a challenging task, due to unique cellular
organization and bioenergetic demands of post-mitotic neurons. It is increasingly …

The fission/division and fusion of mitochondria are fundamental aspects of mitochondrial
biology. The balance of fission and fusion sets the length of mitochondria in cells to serve …

Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …

Neural stem cells in the adult mammalian hippocampus continuously generate new
functional neurons, which modify the hippocampal network and significantly contribute to …