DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Repeated guanine tracts in human and other genomes can form higher-order four stranded
structures, termed quadruplexes. In the human genome they have particular prevalence in …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

The present paper reviews the recent advances in and applications of experimental
techniques used to study interactions between G-quadruplex structures and ligands that are …

This G-rich region of the c-MYC promoter has been shown to form a G-quadruplex structure
that acts as a silencer element for c-MYC transcriptional control. In the present work, we …

The specificity of nucleic acids' binders is crucial for developing this kind of drug, especially
for novel G-quadruplexes' binders. Quindoline derivatives have been developed as G …

Guanine-rich nucleic acid sequences are known to form G-quadruplex-four-stranded DNA or
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …

G-Quadruplex nucleic acids or G-quadruplexes (G4s) are four-stranded DNA or RNA
secondary structures that are formed in guanine-rich sequences. They are widely distributed …

Berberine, as a representative isoquinoline alkaloid, exhibits significant hypolipidemic
activity in both animal models and clinical trials. Recently, a large number of studies on the …