Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Objective Synaptic loss is an early feature of neurodegenerative disease models, and is
severe in post mortem clinical studies, including frontotemporal dementia. Positron emission …

The development of dementia is a devastating aspect of Parkinson's disease (PD), affecting
nearly half of patients within 10 years post-diagnosis. For effective therapies to prevent and …

Abstract Purpose of Review The term primary progressive aphasia (PPA) refers to a diverse
group of dementias that present with prominent and early problems with speech and …

Background Synaptic loss is characteristic of many neurodegenerative diseases; it occurs
early and is strongly related to functional deficits. Objective In this longitudinal observational …

The detection of pathogen-associated molecular patterns can elicit the production of type-I
interferons (IFNs), soluble cytokines that induce a transcriptional state inhibitory to viral …

Introduction Associations between cerebral small vessel disease (SVD) and inflammation
have been largely examined using peripheral blood markers of inflammation, with few …

Introduction In addition to tau pathology and neuronal loss, neuroinflammation occurs in
progressive supranuclear palsy (PSP). However, the prognostic value of the in vivo imaging …

Neuroinflammation is a key driver of neurodegenerative disease, however the tools
available to model this disease biology at the systems level are lacking. We describe a …