Background Many existing bioinformatics predictors are based on machine learning
technology. When applying these predictors in practical studies, their predictive …

Despite recent advances in our understanding of the disease, glioblastoma (GB) continues
to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify …

With advanced technologies to map RNA modifications, our understanding of them has
been revolutionized, and they are seen to be far more widespread and important than …

Background Chemoresistance to temozolomide (TMZ) is a major challenge in the treatment
of glioblastoma (GBM). We previously found that miR-519a functions as a tumor suppressor …

Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM)
5 years ago, tremendous strides have been made in the understanding of these two …

Genetic and other variations frequently affect protein functions. Scientific articles can contain
confusing descriptions about which function or property is affected, and in many cases the …

Understanding protein subcellular localization is vital and indispensable in proteomics
research. Molecular biology and computer science developments have enabled the use of …

The aberrant protein sorting has been observed in many conditions, including complex
diseases, drug treatments, and environmental stresses. It is important to systematically …

Myeloid differentiation primary response protein 88 (MYD88) is a critical universal adapter
that transduces signaling from Toll-like and interleukin receptors to downstream nuclear …

Metastatic medullary thyroid cancer (MTC) is a rare but often aggressive thyroid malignancy
with a 5-year survival rate of less than 40% and few effective therapeutic options. Adoptive T …