The role that Ca2+ plays in ventricular excitation contraction coupling is well defined and
much is known about the marked differences in the spatiotemporal properties of the systolic …

Cardiomyocyte calcium-handling is the key mediator of cardiac excitation-contraction
coupling. In the healthy heart, calcium controls both electrical impulse propagation and …

Optical stimulation in the red/near infrared range recently gained increasing interest, as a
not‐invasive tool to control cardiac cell activity and repair in disease conditions. Translation …

Key points In the majority of species, including humans, increased heart rate increases
cardiac contractility. This change is known as the force–frequency response (FFR). The …

The sarcolemmal Ca 2+ efflux pathways, Na+-Ca 2+-exchanger (NCX) and Ca 2+-ATPase
(PMCA), play a crucial role in the regulation of intracellular Ca 2+ load and Ca 2+ transient …

Although the Na+/K+ pump is one of the key mechanisms responsible for maintaining cell
volume, we have observed experimentally that cell volume remained almost constant during …

A brief historical background on synaptic transmission in relation to Ca2+ dynamics and
short‐term facilitation is described. This study focuses on the mechanisms responsible for …

Components of excitation-contraction (EC)-coupling were compared at 37° C and 22° C to
determine whether hypothermia altered the gain of EC coupling in guinea pig ventricular …

Rationale: cAMP activation of PKA (protein kinase A) stimulates excitation-contraction (EC)
coupling, increasing cardiac contractility. This is clinically achieved by β-ARs (β-adrenergic …

Abstract The cardiac sodium (Na+)/calcium (Ca 2+) exchanger (NCX1) is an electrogenic
membrane transporter that regulates Ca 2+ homeostasis in cardiomyocytes, serving mainly …