New insights into brain BDNF function in normal aging and Alzheimer disease
L Tapia-Arancibia, E Aliaga, M Silhol, S Arancibia - Brain research reviews, 2008 - Elsevier
The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …
It is the case for learning and memory processes which are severely reduced with aging. It is …
Conformations and biological activities of amyloid beta peptide 25-35
L Millucci, L Ghezzi, G Bernardini… - Current Protein and …, 2010 - ingentaconnect.com
Amyloid-β (Aβ) peptide is commonly found in human Alzheimer's disease (AD) brain and is
the main component of Alzheimer amyloid plaques. The predominant forms of Aβ in the …
the main component of Alzheimer amyloid plaques. The predominant forms of Aβ in the …
Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease
Recent human trials of treatments for Alzheimer's disease (AD) have been largely
unsuccessful, raising the idea that treatment may need to be started earlier in the disease …
unsuccessful, raising the idea that treatment may need to be started earlier in the disease …
Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
S Arancibia, M Silhol, F Moulière, J Meffre… - Neurobiology of …, 2008 - Elsevier
We examined the potential protective effect of BDNF against β-amyloid-induced
neurotoxicity in vitro and in vivo in rats. In neuronal cultures, BDNF had specific and dose …
neurotoxicity in vitro and in vivo in rats. In neuronal cultures, BDNF had specific and dose …
The anti‐amnesic and neuroprotective effects of donepezil against amyloid β25‐35 peptide‐induced toxicity in mice involve an interaction with the σ1 receptor
J Meunier, J Ieni, T Maurice - British journal of pharmacology, 2006 - Wiley Online Library
Background and purpose: The acetylcholinesterase inhibitor, donepezil, is also a high
affinity σ1 receptor agonist. We examined the involvement of σ1 receptors in its anti‐amnesic …
affinity σ1 receptor agonist. We examined the involvement of σ1 receptors in its anti‐amnesic …
Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior
Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral …
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral …
Blockade of Tau hyperphosphorylation and Aβ1–42 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ1 receptor agonist, in a …
V Lahmy, J Meunier, S Malmström, G Naert… - …, 2013 - nature.com
The main objective of the present study was to establish whether the mixed σ 1/muscarinic
ligand ANAVEX2-73, shown to be neuroprotective in Alzheimer's disease (AD) models in …
ligand ANAVEX2-73, shown to be neuroprotective in Alzheimer's disease (AD) models in …
[HTML][HTML] Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats
C Zussy, A Brureau, B Delair, S Marchal… - The American journal of …, 2011 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence
of senile plaques and neurofibrillary tangles, accompanied by synaptic and neuronal loss …
of senile plaques and neurofibrillary tangles, accompanied by synaptic and neuronal loss …
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats
C Zussy, A Brureau, E Keller, S Marchal, C Blayo… - PloS one, 2013 - journals.plos.org
Alzheimer's disease (AD) is a neurodegenerative pathology associated with aging
characterized by the presence of senile plaques and neurofibrillary tangles that finally result …
characterized by the presence of senile plaques and neurofibrillary tangles that finally result …
A neural cell adhesion molecule–derived peptide reduces neuropathological signs and cognitive impairment induced by Aβ25-35
B Klementiev, T Novikova, V Novitskaya, PS Walmod… - Neuroscience, 2007 - Elsevier
By means of icv administration of preaggregated oligomeric β-amyloid (Aβ) 25-35 peptide it
was possible in rats to generate neuropathological signs related to those of early stages of …
was possible in rats to generate neuropathological signs related to those of early stages of …