Pathogenetic and therapeutic applications of tumor necrosis factor-α (TNF-α) in major depressive disorder: a systematic review

K Ma, H Zhang, Z Baloch - International journal of molecular sciences, 2016 - mdpi.com
Major depressive disorder (MDD) is characterized by mood, vegetative, cognitive, and even
psychotic symptoms and signs that can cause substantial impairments in quality of life and …

Anti-TNF-α Compounds as a Treatment for Depression

S Uzzan, AN Azab - Molecules, 2021 - mdpi.com
Millions of people around the world suffer from psychiatric illnesses, causing unbearable
burden and immense distress to patients and their families. Accumulating evidence …

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

Y Cheng, S Desse, A Martinez, RJ Worthen… - Brain, behavior, and …, 2018 - Elsevier
Recovery from major depressive disorder is difficult, particularly in patients who are
refractory to antidepressant treatments. To examine factors that regulate recovery, we …

The involvement of TNF-α in cognitive dysfunction associated with major depressive disorder: an opportunity for domain specific treatments

B Bortolato, AF Carvalho… - Current …, 2015 - ingentaconnect.com
Major depressive disorder is a highly prevalent, chronic and recurring disorder, associated
with substantial impairment in cognitive and interpersonal functions. Accumulating evidence …

Targeting inflammation: a potential approach for the treatment of depression

S Bhatt, T Devadoss, NK Jha, M Baidya, G Gupta… - Metabolic Brain …, 2023 - Springer
Major depressive disorder (MDD) or Depression is one of the serious neuropsychiatric
disorders affecting over 280 million people worldwide. It is 4th important cause of disability …

The cytokine network in the pathogenesis of major depressive disorder. Close to translation?

MC Petralia, E Mazzon, P Fagone, MS Basile… - Autoimmunity …, 2020 - Elsevier
Major depressive disorder (MDD) is a common condition that afflicts the general population
across a broad spectrum of ages and social backgrounds. MDD has been identified by the …

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

W Zhu, FS Cao, J Feng, HW Chen, JR Wan, Q Lu… - Neuroscience, 2017 - Elsevier
Lipopolysaccharide (LPS) might affect the central nervous system by causing
neuroinflammation, which subsequently leads to brain damage and dysfunction. In this …

Cognitive dysfunction in depression–pathophysiology and novel targets

A F. Carvalho, K K. Miskowiak… - CNS & Neurological …, 2014 - benthamdirect.com
Major depressive disorder (MDD) is associated with cognitive dysfunction encompassing
several domains, including memory, executive function, processing speed and attention …

Developmental minocycline treatment reverses the effects of neonatal immune activation on anxiety-and depression-like behaviors, hippocampal inflammation, and …

J Majidi, M Kosari-Nasab, AA Salari - Brain research bulletin, 2016 - Elsevier
Neonatal infection is associated with increased lifetime risk for neuropsychiatric disorders
including anxiety and depression, with evidence showing that dysregulation of the …

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

TD Şahin, A Karson, F Balcı, Y Yazır… - Behavioural brain …, 2015 - Elsevier
Previous findings have shown that patients with depression express higher levels of
proinflammatory cytokines such as TNF-α and IL-6. We have recently found that Infliximab (a …