In striated muscles, the rapid production of macroscopic levels of force and displacement
stems directly from highly ordered and hierarchical protein organization, with the sarcomere …

Understanding the molecular interactions among components of cardiac Z-discs and their
role in signaling has become pivotal in explaining long-and short-term regulation of cardiac …

Gain a well-rounded understanding of the principles underlying stretching and flexibility with
the updated third edition of Science of Flexibility. This practical text includes illustrated …

Titin, a giant filamentous polypeptide, is believed to play a fundamental role in maintaining
sarcomeric structural integrity and developing what is known as passive force in muscle …

mAbs specific for titin or nebulin were characterized by immunoblotting and fluorescence
microscopy. Immunoelectron microscopy on relaxed chicken breast muscle revealed unique …

Recent studies have demonstrated a role for the elastic protein titin in active muscle, but the
mechanisms by which titin plays this role remain to be elucidated. In active muscle, Ca2+ …

The giant muscle protein titin has become a focus of research interests in the field of muscle
mechanics due to its importance for passive muscle stiffness. Here we summarize research …

The protein titin has been localized by electron microscopy of myofibrils labelled with
monoclonal antibodies. The data are consistent with individual titin molecules extending …

Biopsies from the vastus lateralis muscle of male weightlifters (WL; n= 6; X+/-SE, age=
27.0+/-2.1 years), and non-weight-trained men (CON; n= 7; age= 22.0+/-2.0) were compared …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …