BACKGROUND Achieving the correct spatial and temporal expression of germ-cell-specific
genes is fundamental to the production of viable healthy spermatozoa. Notably, post …

Bladder cancer is a histologically and clinically heterogenous disease. Most bladder
cancers are urothelial carcinomas, which frequently develop distinct histological subtypes …

Molecular therapies are hallmarks of “personalized” medicine, but how tumors adapt to
these agents is not well-understood. Here we show that small-molecule inhibitors of …

Background Progression of conventional urothelial carcinoma of the bladder to a tumor with
unique microscopic features referred to as micropapillary carcinoma is coupled with …

Genes regulated by the same miRNA can be discovered by virtue of their coexpression at
the transcriptional level and the presence of a conserved miRNA-binding site in their 3 …

microRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression
by targeting specific mRNAs. microRNAs play a role in several physiological processes in …

Berberine (BBR) is an isoquinoline alkaloid found in different plant families such as
Berberidaceae, Ranunculaceae, and Papaveraceae. BBR is well-known for its anti …

The distribution of biomolecules within cells changes upon aging and diseases. To
quantitatively determine the spatial distribution of components inside cells, we built the user …

Upregulation of Pin1 was shown to advance the functioning of several oncogenic pathways.
It was recently shown that Pin1 is potentially an excellent prognostic marker and can also …

Context.—Bladder cancer is a heterogeneous disease that exhibits a wide spectrum of
clinical and pathologic features. The classification of bladder cancer has been traditionally …