Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

Heart failure has reached epidemic proportions in a progressively ageing population. The
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …

Aging increases the risk of atherosclerotic cardiovascular disease which is associated with
arterial senescence; however, the mechanisms responsible for the development of cellular …

DNA damage is a causative factor in ageing of the vasculature and other organs. One of the
most important vascular ageing features is reduced nitric oxide (NO) soluble guanylate …

Cardiovascular diseases are the leading cause of death globally. Within cardiovascular
aging, arterial aging holds significant importance, as it involves structural and functional …

Phosphodiesterases regulate levels of the cyclic nucleotides cyclic adenosine
monophosphate and cyclic guanosine monophosphate. Thanks to regulation by specific …

Cardiovascular diseases are the number one cause of death globally. The most important
determinant of cardiovascular health is a person's age. Aging results in structural changes …

Age-related cardiovascular diseases (CVDs) remain among the leading global causes of
death, and vascular smooth muscle cell (VSMC) remodeling plays an essential role in its …

MicroRNAs (miRNAs) are small non-coding RNAs that play an important role by controlling
gene expression in the cytoplasm in almost all biological pathways. Recently, scientists …