Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …

Brain ischemia initiates a complex cascade of metabolic events, several of which involve the
generation of nitrogen and oxygen free radicals. These free radicals and related reactive …

Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes,
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …

Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …

Poly (ADP-ribose) polymerase (PARP, EC 2.4. 2.30), an abundant nuclear protein activated
by DNA nicks, mediates cell death in vitro by nicotinamide adenine dinucleotide (NAD) …

The abundant nuclear enzyme poly (ADP-ribose) polymerase (PARP) synthesizes poly
(ADP-ribose) in response to DNA strand breaks. During almost all forms of apoptosis, PARP …

Proteases play a crucial role in apoptosis or programmed cell death. The aim of this review
is to highlight the purpose for which these proteases are activated, ie, to specifically cleave a …

The flow of new information on gene expression related to apoptosis has been relentless in
the last several years. This has also been the case with respect to gene expression after …

A transient burst of poly (ADP-ribosyl) ation of nuclear proteins occurs early, prior to
commitment to death, in human osteosarcoma cells undergoing apoptosis, followed by …

▪ Abstract Evidence is emerging that biotin participates in processes other than classical
carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression …