People are more often exposed to low as opposed to high doses of ionising radiation (IR).
Knowledge on the health risks associated with exposures to ionising radiation above 100 …

The timely and precise repair of DNA damage, or more specifically DNA double-strand
breaks (DSBs)–the most deleterious DNA lesions, is crucial for maintaining genome integrity …

Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase
in the brain and contribute to brain damage and neurological disorders. Changes in the …

We recently reported that when low doses of ionizing radiation induce low numbers of DNA
double-strand breaks (DSBs) in G 2-phase cells, about 50% of them are repaired by …

Four repair pathways process DNA double-strand breaks (DSBs). Among these pathways
the homologous recombination repair (HRR) subpathway of gene conversion (GC) affords …

Posttranslational modifications (PTMs) of histone proteins are important for various cellular
processes including regulation of gene expression and chromatin structure, DNA damage …

Epigenetics refers to changes in cell characteristics that occur independently of
modifications to the deoxyribonucleic acid (DNA) sequence. Alterations mediated by …

Current approaches have limitations in providing insight into the functional properties of
particular nucleosomes in their native molecular environment. Here we describe a simple …

Cells are constantly exposed to various sources of DNA damage that pose a threat to their
genomic integrity. One of the most common types of DNA breaks are single-strand breaks …

Mapping the genome‐wide distribution of DNA lesions is key to understanding damage
signalling and DNA repair in the context of genome and chromatin structure. Analytical tools …