Our understanding of the evolution, formation, and pathological disruption of human brain
circuits is impeded by a lack of comprehensive data on the developing brain transcriptome …

Background Adaptation to low oxygen by changing gene expression is vitally important for
cell survival and tissue development. The sprouting of new blood vessels, initiated from …

In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental
property of the mammalian CNS. However, the neurodevelopmental function of the human …

Proper connectivity of the nervous system requires temporal and spatial control of axon
guidance signaling. As commissural axons navigate across the CNS midline, ROBO …

Dopaminergic neurons from the ventral mesencephalon/diencephalon (mesodiencephalon)
form vital pathways constituting the majority of the brain's dopamine systems …

The genetic analysis of nontumorigenic radiation hybrids generated by transfer of
chromosome 3 fragments into the tumorigenic OV‐90 ovarian cancer cell line identified the …

Background Longitudinal axons grow parallel to the embryonic midline to connect distant
regions of the central nervous system. Previous studies suggested that repulsive midline …

Formation of the neural tube is the morphological hallmark for development of the embryonic
central nervous system (CNS). Therefore, neural tube development is a crucial step in the …

In the developing hindbrain, facial branchiomotor (FBM) neurons migrate caudally from
rhombomere 4 (r4) to r6 to establish the circuit that drives jaw movements. Although the …

The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for
treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention …