A key point of immunity against protozoan Leishmania parasites is the development of an
optimal T cell response, which includes a low apoptotic rate, high proliferative activity and …

Intracellular phagosomal pathogens represent a formidable challenge for innate immune
cells, as, paradoxically, these phagocytic cells can act as both host cells that support …

This study evaluated the effects of 2-amino-thiophene derivatives on the promastigote and
amastigote forms of Leishmania (Leishmania) amazonensis and their possible mechanisms …

Infection by protozoan parasites is part of the most common Tropical Neglected Diseases. In
the case of leishmaniasis, several millions of people are at risk of contracting the disease. In …

Leishmaniasis is a neglected tropical disease affecting millions of people around the world
caused by organisms of the genus Leishmania. Parasite escape mechanisms of the immune …

Adenosine is an endogenously released purine nucleoside that signals through four widely
expressed G protein-coupled receptors: A1, A2A, A2B, and A3. Of these, A2AR is …

ENTPDases are enzymes known for hydrolyzing extracellular nucleotides and playing an
essential role in controlling the nucleotide signaling via nucleotide/purinergic receptors P2 …

Nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes that belong to the
GDA1/CD39 protein superfamily. These enzymes catalyze the hydrolysis of ATP and ADP to …

Ecto-nucleotidase activity is involved in the infection process of Leishmania and various
other parasites that enables modulation of host immune responses to promote disease …

Leishmania braziliensis is a pathogenic protozoan parasite that causes American
Tegumentary Leishmaniasis (ATL), an important tropical neglected disease. ENTPDases …