Stem cell based therapies for age-related macular degeneration: the promises and the challenges
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …
Development of human embryonic stem cell therapies for age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults
and ultimately leads to the death of photoreceptor cells in the macular area of the neural …
and ultimately leads to the death of photoreceptor cells in the macular area of the neural …
Oxidative Stress and Lipid Accumulation Augments Cell Death in LDLR-Deficient RPE Cells and Ldlr −/− Mice
PG Sreekumar, F Su, C Spee, E Araujo, S Nusinowitz… - Cells, 2022 - mdpi.com
Lipid peroxidation from oxidative stress is considered a major contributor to age-related
macular degeneration (AMD). The retina is abundant with circulating low-density …
macular degeneration (AMD). The retina is abundant with circulating low-density …
Development of 3D printed Bruch's membrane-mimetic substance for the maturation of retinal pigment epithelial cells
Retinal pigment epithelium (RPE) is a monolayer of the pigmented cells that lies on the thin
extracellular matrix called Bruch's membrane. This monolayer is the main component of the …
extracellular matrix called Bruch's membrane. This monolayer is the main component of the …
Sodium-Iodate Injection Can replicate retinal degenerative Disease Stages in pigmented mice and Rats: non-invasive Follow-Up using OCT and ERG
C Koster, KT van Den Hurk, JB Ten Brink… - International journal of …, 2022 - mdpi.com
Purpose: The lack of suitable animal models for (dry) age-related macular degeneration
(AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented …
(AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented …
Mobilizing endogenous stem cells for retinal repair
H Yu, THK Vu, KS Cho, C Guo, DF Chen - Translational Research, 2014 - Elsevier
Irreversible vision loss is most often caused by the loss of function and subsequent death of
retinal neurons, such as photoreceptor cells—the cells that initiate vision by capturing and …
retinal neurons, such as photoreceptor cells—the cells that initiate vision by capturing and …
Stem cell therapies for age-related macular degeneration: the past, present, and future
In the developed world, age-related macular degeneration (AMD) is one of the major causes
of irreversible blindness in the elderly. Although management of neovascular AMD (wet …
of irreversible blindness in the elderly. Although management of neovascular AMD (wet …
Enhancing RPE cell-based therapy outcomes for AMD: the role of Bruch's membrane
Age-related macular degeneration (AMD) is the leading cause of legal blindness in older
people in the developed world. The disease involves damage to the part of the retina …
people in the developed world. The disease involves damage to the part of the retina …
Treatment of inherited retinal dystrophies with somatic cell therapy medicinal product: a review
Inherited retinal dystrophies and retinal degenerations related to more common diseases
(ie, age-related macular dystrophy) are a major issue and one of the main causes of low …
(ie, age-related macular dystrophy) are a major issue and one of the main causes of low …
A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells
Purpose To create new immunodeficient Royal College of Surgeons (RCS) rats by
introducing the defective MerTK gene into athymic nude rats. Methods Female homozygous …
introducing the defective MerTK gene into athymic nude rats. Methods Female homozygous …