The role of the microtubule cytoskeleton in neurodevelopmental disorders

M Lasser, J Tiber, LA Lowery - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …

Microtubules: From understanding their dynamics to using them as potential therapeutic targets

Y Ilan - Journal of cellular physiology, 2019 - Wiley Online Library
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

TAOK2 rescues autism-linked developmental deficits in a 16p11. 2 microdeletion mouse model

R Scharrenberg, M Richter, O Johanns, DP Meka… - Molecular …, 2022 - nature.com
The precise development of the neocortex is a prerequisite for higher cognitive and
associative functions. Despite numerous advances that have been made in understanding …

[HTML][HTML] Moving through the crowd. Where are we at understanding physiological axon growth?

E Alfadil, F Bradke - Seminars in cell & developmental biology, 2023 - Elsevier
Axon growth enables the rapid wiring of the central nervous system. Understanding this
process is a prerequisite to retriggering it under pathological conditions, such as a spinal …

Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons

C Deng, M Moradi, S Reinhard, C Ji… - Journal of Cell …, 2021 - journals.biologists.com
In neurons, the endoplasmic reticulum (ER) forms a highly dynamic network that enters
axons and presynaptic terminals and plays a central role in Ca2+ homeostasis and synapse …

The functional architecture of axonal actin

MJ Papandréou, C Leterrier - Molecular and Cellular Neuroscience, 2018 - Elsevier
The cytoskeleton builds and supports the complex architecture of neurons. It orchestrates
the specification, growth, and compartmentation of the axon: axon initial segment, axonal …

Centrosomal actin assembly is required for proper mitotic spindle formation and chromosome congression

M Plessner, J Knerr, R Grosse - IScience, 2019 - cell.com
Cytoskeletal cross talk between actin filaments and microtubules is a common mechanism
governing the assembly of cellular structures, ie, during filopodia formation or cilia …

[HTML][HTML] Regulation of actin filament assembly and disassembly in growth cone motility and axon guidance

F Schneider, I Metz, MB Rust - Brain Research Bulletin, 2023 - Elsevier
Directed outgrowth of axons is fundamental for the establishment of neuronal networks.
Axon outgrowth is guided by growth cones, highly motile structures enriched in filamentous …

With the permission of microtubules: an updated overview on microtubule function during axon pathfinding

C Sánchez-Huertas, E Herrera - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
During the establishment of neural circuitry axons often need to cover long distances to
reach remote targets. The stereotyped navigation of these axons defines the connectivity …

CKAP5 enables formation of persistent actin bundles templated by dynamically instable microtubules

J Sabo, MD Zdimalova, PG Slater, V Dostal, S Herynek… - Current Biology, 2024 - cell.com
Cytoskeletal rearrangements and crosstalk between microtubules and actin filaments are
vital for living organisms. Recently, an abundantly present microtubule polymerase, CKAP5 …