Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in
healthy organisms and in disease. TNF is involved in the development and proper …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

The receptor-interacting protein kinase 1 (RIPK1) is recognized as a master upstream
regulator that controls cell survival and inflammatory signaling as well as multiple cell death …

Pyroptosis, apoptosis, and necroptosis are mainly programmed cell death (PCD) pathways
for host defense and homeostasis. PANoptosis is a newly distinct inflammatory PCD …

Abstract Receptor Interacting Protein Kinases (RIPKs) are a family of Ser/Thr/Tyr kinases
whose functions, regulation and pathophysiologic roles have remained an enigma for a long …

Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of
TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 …