Combinatorial approaches for cancer treatment using oncolytic viruses: projecting the perspectives through clinical trials outcomes
Recent cancer immunotherapy breakthroughs have fundamentally changed oncology and
revived the fading hope for a cancer cure. The immune checkpoint inhibitors (ICI) became …
revived the fading hope for a cancer cure. The immune checkpoint inhibitors (ICI) became …
Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses
WN Wulan, D Heydet, EJ Walker, ME Gahan… - Frontiers in …, 2015 - frontiersin.org
Most viruses with non-segmented single stranded RNA genomes complete their life cycle in
the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm …
the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm …
Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy
The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that
includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral …
includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral …
[HTML][HTML] Paramyxovirus RNA synthesis, mRNA editing, and genome hexamer phase: a review
D Kolakofsky - Virology, 2016 - Elsevier
The recent flurry of high resolution structures of Negative Strand RNA Virus RNA-dependent
RNA polymerases has rekindled interest in the manner in which these polymerases, and in …
RNA polymerases has rekindled interest in the manner in which these polymerases, and in …
Analysis of ribonucleotide 5′-triphosphate analogs as potential inhibitors of Zika virus RNA-dependent RNA polymerase by using nonradioactive polymerase assays
G Lu, GR Bluemling, P Collop, M Hager… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Zika virus (ZIKV) is an emerging human pathogen that is spreading rapidly through the
Americas and has been linked to the development of microcephaly and to a dramatically …
Americas and has been linked to the development of microcephaly and to a dramatically …
RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V
MR Braun, LR Deflubé, SL Noton, ME Mawhorter… - PLoS …, 2017 - journals.plos.org
The large polymerase subunit (L) of non-segmented negative strand RNA viruses
transcribes viral mRNAs and replicates the viral genome. Studies with VSV have shown that …
transcribes viral mRNAs and replicates the viral genome. Studies with VSV have shown that …
An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity
We report an in vitro RNA synthesis assay for the RNA-dependent RNA polymerase (RdRP)
of rabies virus (RABV). We expressed RABV large polymerase protein (L) in insect cells from …
of rabies virus (RABV). We expressed RABV large polymerase protein (L) in insect cells from …
The C-terminal domain of the Sudan ebolavirus L protein is essential for RNA binding and methylation
C Valle, B Martin, F Debart, JJ Vasseur, I Imbert… - Journal of …, 2020 - Am Soc Microbiol
The large (L) protein of Ebola virus is a key protein for virus replication. Its N-terminal region
harbors the RNA-dependent RNA polymerase activity, and its C terminus contains a cap …
harbors the RNA-dependent RNA polymerase activity, and its C terminus contains a cap …
Selective metal ion utilization contributes to the transformation of the activity of yeast polymerase η from DNA polymerization toward RNA polymerization
Polymerase eta (Polη) is a translesion synthesis DNA polymerase directly linked to cancer
development. It can bypass several DNA lesions thereby rescuing DNA damage-stalled …
development. It can bypass several DNA lesions thereby rescuing DNA damage-stalled …
The role of sequence context, nucleotide pool balance and stress in 2′-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA
J Wang, H Dong, YH Chionh, ME McBee… - Nucleic acids …, 2016 - academic.oup.com
Abstract The misincorporation of 2′-deoxyribonucleotides (dNs) into RNA has important
implications for the function of non-coding RNAs, the translational fidelity of coding RNAs …
implications for the function of non-coding RNAs, the translational fidelity of coding RNAs …