Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

FM Kashkooli, M Soltani, M Souri - Journal of controlled release, 2020 - Elsevier
Advances in nanomedicine, including early cancer detection, targeted drug delivery, and
personalized approaches to cancer treatment are on the rise. For example, targeted drug …

Recent advances in PLGA-based biomaterials for bone tissue regeneration

S Jin, X Xia, J Huang, C Yuan, Y Zuo, Y Li, J Li - Acta biomaterialia, 2021 - Elsevier
Bone regeneration is an interdisciplinary complex lesson, including but not limited to
materials science, biomechanics, immunology, and biology. Having witnessed impressive …

Controlled drug delivery vehicles for cancer treatment and their performance

S Senapati, AK Mahanta, S Kumar… - Signal transduction and …, 2018 - nature.com
Although conventional chemotherapy has been successful to some extent, the main
drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse …

Wireless on-demand drug delivery

SM Mirvakili, R Langer - Nature Electronics, 2021 - nature.com
Wireless on-demand drug delivery systems exploit exogenous stimuli—acoustic waves,
electric fields, magnetic fields and electromagnetic radiation—to trigger drug carriers. The …

Designing hydrogels for controlled drug delivery

J Li, DJ Mooney - Nature Reviews Materials, 2016 - nature.com
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery
and have found clinical use. Hydrogels can provide spatial and temporal control over the …

Transdermal microneedles for the programmable burst release of multiple vaccine payloads

KTM Tran, TD Gavitt, NJ Farrell, EJ Curry… - Nature Biomedical …, 2021 - nature.com
Repeated bolus injections are associated with higher costs and poor compliance and can
hinder the implementation of global immunization campaigns. Here, we report the …

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

S Mitragotri, PA Burke, R Langer - Nature reviews Drug discovery, 2014 - nature.com
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

X Han, A Alu, H Liu, Y Shi, X Wei, L Cai, Y Wei - Bioactive Materials, 2022 - Elsevier
Biotherapy has recently become a hotspot research topic with encouraging prospects in
various fields due to a wide range of treatments applications, as demonstrated in preclinical …

Drug delivery systems for programmed and on-demand release

P Davoodi, LY Lee, Q Xu, V Sunil, Y Sun, S Soh… - Advanced drug delivery …, 2018 - Elsevier
With the advancement in medical science and understanding the importance of
biodistribution and pharmacokinetics of therapeutic agents, modern drug delivery research …

Crossing the blood–brain barrier: recent advances in drug delivery to the brain

MM Patel, BM Patel - CNS drugs, 2017 - Springer
CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …