Aim: The “2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid
Hemorrhage” replaces the 2012 “Guidelines for the Management of Aneurysmal …

Subarachnoid hemorrhage (SAH) is an acute cerebrovascular event which can have
devastating effects on the central nervous system as well as a profound impact on several …

Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …

Objective: To develop a clinical practice guideline for red blood cell transfusion in adult
trauma and critical care. Design: Meetings, teleconferences and electronic-based …

Aneurysmal subarachnoid haemorrhage is a neurological syndrome with complex systemic
complications. The rupture of an intracranial aneurysm leads to the acute extravasation of …

Massive transfusion (MT) is a lifesaving treatment of hemorrhagic shock, but can be
associated with significant complications. The lethal triad of acidosis, hypothermia, and …

As it is often assumed that delayed cerebral ischemia (DCI) after subarachnoid hemorrhage
(SAH) is caused by vasospasm, clinical trials often focus on prevention of vasospasm with …

Acute ischaemic and haemorrhagic stroke account for significant disability and morbidity
burdens worldwide. The myeloid arm of the peripheral innate immune system is critical in …

Traumatic brain injury (TBI) is an important cause of morbidity and mortality worldwide. TBI
patients frequently suffer from lung complications and acute respiratory distress syndrome …

Purpose We assessed outcomes in brain-injured patients after implementation of a multi-
faceted approach to reduce respiratory complications in intensive care units. Methods …