Tight coupling between biochemical and mechanical properties of the actin cytoskeleton drives a large range of cellular processes including polarity establishment, morphogenesis …
MP Murrell, ML Gardel - Proceedings of the National …, 2012 - National Acad Sciences
Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross- linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted …
RJ Hung, CW Pak, JR Terman - Science, 2011 - science.org
Different types of cell behavior, including growth, motility, and navigation, require actin proteins to assemble into filaments. Here, we describe a biochemical process that was able …
S Rajan, J Yoon, H Wu, S Srapyan… - Proceedings of the …, 2023 - National Acad Sciences
Cellular form and function are controlled by the assembly and stability of actin cytoskeletal structures—but disassembling/pruning these structures is equally essential for the plasticity …
BR McCullough, EE Grintsevich, CK Chen, H Kang… - Biophysical journal, 2011 - cell.com
The actin regulatory protein, cofilin, increases the bending and twisting elasticity of actin filaments and severs them. It has been proposed that filaments partially decorated with …
Cells use a large repertoire of proteins to remodel the actin cytoskeleton. Depending on the proteins involved, F-actin is organized in specialized protrusions such as lamellipodia or …
The cellular cytoskeleton is crucial for many cellular functions such as cell motility and wound healing, as well as other processes that require shape change or force generation …
Migrating cells nucleate focal adhesions (FAs) at the cell front and disassemble them at the rear to allow cell translocation. FAs are made of a multiprotein complex, the adhesome …
During bacterial cell division, the tubulin-homolog FtsZ forms a ring-like structure at the center of the cell. This Z-ring not only organizes the division machinery, but treadmilling of …