The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Actin dynamics, architecture, and mechanics in cell motility

L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex

MP Murrell, ML Gardel - Proceedings of the National …, 2012 - National Acad Sciences
Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross-
linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted …

Direct redox regulation of F-actin assembly and disassembly by Mical

RJ Hung, CW Pak, JR Terman - Science, 2011 - science.org
Different types of cell behavior, including growth, motility, and navigation, require actin
proteins to assemble into filaments. Here, we describe a biochemical process that was able …

Disassembly of bundled F-actin and cellular remodeling via an interplay of Mical, cofilin, and F-actin crosslinkers

S Rajan, J Yoon, H Wu, S Srapyan… - Proceedings of the …, 2023 - National Acad Sciences
Cellular form and function are controlled by the assembly and stability of actin cytoskeletal
structures—but disassembling/pruning these structures is equally essential for the plasticity …

Cofilin-linked changes in actin filament flexibility promote severing

BR McCullough, EE Grintsevich, CK Chen, H Kang… - Biophysical journal, 2011 - cell.com
The actin regulatory protein, cofilin, increases the bending and twisting elasticity of actin
filaments and severs them. It has been proposed that filaments partially decorated with …

Cofilin cooperates with fascin to disassemble filopodial actin filaments

D Breitsprecher, SA Koestler, I Chizhov… - Journal of cell …, 2011 - journals.biologists.com
Cells use a large repertoire of proteins to remodel the actin cytoskeleton. Depending on the
proteins involved, F-actin is organized in specialized protrusions such as lamellipodia or …

Myosin II activity softens cells in suspension

CJ Chan, AE Ekpenyong, S Golfier, W Li, KJ Chalut… - Biophysical journal, 2015 - cell.com
The cellular cytoskeleton is crucial for many cellular functions such as cell motility and
wound healing, as well as other processes that require shape change or force generation …

Fascin plays a role in stress fiber organization and focal adhesion disassembly

N Elkhatib, MB Neu, C Zensen, KM Schmoller… - Current Biology, 2014 - cell.com
Migrating cells nucleate focal adhesions (FAs) at the cell front and disassemble them at the
rear to allow cell translocation. FAs are made of a multiprotein complex, the adhesome …

Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA

P Caldas, M López-Pelegrín, DJG Pearce… - Nature …, 2019 - nature.com
During bacterial cell division, the tubulin-homolog FtsZ forms a ring-like structure at the
center of the cell. This Z-ring not only organizes the division machinery, but treadmilling of …