Human mitochondrial protein complexes revealed by large-scale coevolution analysis and deep learning-based structure modeling

J Pei, J Zhang, Q Cong - Bioinformatics, 2022 - academic.oup.com
Motivation Recent development of deep-learning methods has led to a breakthrough in the
prediction accuracy of 3D protein structures. Extending these methods to protein pairs is …

[HTML][HTML] Timing of dimerization of the bc1 complex during mitochondrial respiratory chain assembly

K Stephan, M Ott - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2020 - Elsevier
The mitochondrial bc 1 complex plays an important role in mitochondrial respiration. It
transfers electrons from ubiquinol to the soluble electron shuttle cytochrome c and thereby …

A family of novel immune systems targets early infection of nucleus-forming jumbo phages

Y Li, J Guan, S Hareendranath, E Crawford, DA Agard… - bioRxiv, 2022 - biorxiv.org
Jumbo bacteriophages of the⌽ KZ-like family are characterized by large genomes (> 200 kb)
and the remarkable ability to assemble a proteinaceous nucleus-like structure. The nucleus …

The cytochrome b carboxyl terminal region is necessary for mitochondrial complex III assembly

D Flores-Mireles, Y Camacho-Villasana… - Life Science …, 2023 - life-science-alliance.org
Mitochondrial bc 1 complex from yeast has 10 subunits, but only cytochrome b (Cyt b)
subunit is encoded in the mitochondrial genome. Cyt b has eight transmembrane helices …

Insights into conformational changes in cytochrome b during the early steps of its maturation

A Carlström, M Ott - FEBS letters, 2024 - Wiley Online Library
Membrane proteins carrying redox cofactors are key subunits of respiratory chain
complexes, yet the exact path of their folding and maturation remains poorly understood …

DPC29 Promotes Mitochondrial Translation Post-Initation in Saccharomyces cerevisiae

KA Hubble - 2022 - rdw.rowan.edu
Although the cytosolic and bacterial translation systems are well studied, much less is
known about translation in mitochondria. In the yeast Saccharomyces cerevisiae …

Structural and functional studies of protein complexes involved in energy metabolism

J Berndtsson - 2021 - diva-portal.org
Mitochondria are eukaryotic organelles with a multitude of functions including biosynthesis
of molecules and cellular regulation. Most prominently though is their role in energy …

Organization and regulation of mitochondrial gene expression

R Salvatori - 2020 - diva-portal.org
Mitochondria possess their own genome, remnant of the ancestral eubacterial
endosymbiont DNA. This mitochondrial genome encodes mostly few key subunits of the …

Biogenesis of the bc1 complex in mitochondria

K Stephan - 2020 - diva-portal.org
Mitochondria perform a variety of tasks, but the function they are most prominent for is the
energy conversion to form ATP, the universal energy equivalent of the cell. The majority of …