Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

A comprehensive understanding of RNA structure will provide fundamental insights into the
cellular function of both coding and non-coding RNAs. Although many RNA structures have …

Interpreting electron cryo-microscopy (cryo-EM) maps with atomic models requires high
levels of expertise and labour-intensive manual intervention in three-dimensional computer …

Accurate predictions of RNA secondary structures can help uncover the roles of functional
non-coding RNAs. Although machine learning-based models have achieved high …

Antibacterial agents target the products of essential genes but rarely achieve complete
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …

Most short sequences can be precisely written into a selected genomic target using prime
editing; however, it remains unclear what factors govern insertion. We design a library of …

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types
of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each …

Triple-negative breast cancer (TNBC) is highly aggressive with a poor clinical prognosis and
no targeted therapy. The c-Myc protein is a master transcription factor and a potential …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in
cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for …

Aromatase inhibition is an efficient endocrine therapy to block ectopic estrogen production
for postmenopausal estrogen receptor (ER)-positive breast cancer patients, but many …