Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

Arguably targeting is one of the biggest problems for controlled drug delivery. In the case
that drugs can be directed with high efficiency to the target tissue, side effects of medication …

Antibody-coated nanoparticles have recently attracted considerable attention, with the focus
falling on diagnostics. Nevertheless, controlled antibody bioconjugation remains a …

Extracellular proteolysis is frequently dysregulated in disease and can generate proteoforms
with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that …

Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the
maintenance of the various other physiological processes. Aging is accompanied by a …

Certain Chinese herbal medicines have antipyretic effects in both animal and human clinical
practice. However, no report indicates their antipyretic effects on heat-stressed cells. The …

The mammalian target of rapamycin (mTOR) signaling cascade is a key regulatory pathway
controlling initiation of messenger RNA in mammalian cells. Although dysregulation of …

Benzene, toluene, ethylbenzene and xylene, also known as BTEX, are released into
environmental media by petroleum product exploratory and exploitative activities and are …

Early evaluation of the therapy efficiency can promote the development of anti-tumor drugs
and optimization of the treatment method. Caspase-3 is a key biomarker for early apoptosis …

Background Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis
pathway and plays a crucial role in cancer development and progression. However, few …