The unexpected repurposing of nuclear transport proteins from their function in interphase to
an equally vital and very different set of functions in mitosis was very surprising. The multi …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Abstract Lamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the
nuclear envelope post mitosis. Here we show that LBR depletion induces mitotic defects …

Laminopathies are genetic diseases due to mutations or altered post‐translational
processing of nuclear envelope/lamina proteins. The majority of laminopathies are caused …

Cell division is tightly regulated and requires an expanded energy supply. However, how
this energy is generated remains unclear. Here, we establish a correlation between two …

Cells have developed highly sophisticated ways to accurately pass on their genetic
information to the daughter cells. In animal cells, which undergo open mitosis, the nuclear …

The metazoan nucleus is disassembled and re-built at every mitotic cell division. The
nuclear envelope, including nuclear pore complexes, breaks down at the beginning of …

Lamin B receptor (LBR) is an integral protein of the inner nuclear membrane, containing a
hydrophilic N-terminal end protruding into the nucleoplasm, eight hydrophobic segments …

The nuclear import receptor karyopherin β1 (KPNB1) is involved in the nuclear import of
most proteins and in the regulation of multiple mitotic events. Upregulation of KPNB1 has …

Cell migration plays an important role in many physiological and pathological settings,
ranging from embryonic development to cancer metastasis. Currently, accumulating data …