Thioredoxin-1: A promising target for the treatment of allergic diseases

J Wang, J Zhou, C Wang, A Fukunaga, S Li… - Frontiers in …, 2022 - frontiersin.org
Thioredoxin-1 (Trx1) is an important regulator of cellular redox homeostasis that comprises a
redox-active dithiol. Trx1 is induced in response to various stress conditions, such as …

Anti-allergic and anti-inflammatory effects and molecular mechanisms of thioredoxin on respiratory system diseases

JD Zhou, CX Wang, JL Wu, A Fukunaga… - Antioxidants & Redox …, 2020 - liebertpub.com
Significance: The pathogenesis and progression of allergic inflammation in the respiratory
system are closely linked to oxidative stress. Thioredoxin (TRX) is an essential redox …

The role of T cells and macrophages in asthma pathogenesis: a new perspective on mutual crosstalk

X Zhu, J Cui, L Yi, J Qin, W Tulake… - Mediators of …, 2020 - Wiley Online Library
Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or
macrophage dysfunction plays a particularly significant role in asthma pathogenesis …

[HTML][HTML] The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)

F Varyani, S Löser, KJ Filbey, Y Harcus, C Drurey… - Mucosal …, 2022 - Elsevier
Macrophage migration inhibitory factor (MIF) is a key innate immune mediator with
chemokine-and cytokine-like properties in the inflammatory pathway. While its actions on …

Isopsoralen ameliorates rheumatoid arthritis by targeting MIF

Y Han, J Wang, S Li, Y Li, Y Zhang, R Zhang… - Arthritis Research & …, 2021 - Springer
Background Isopsoralen (IPRN), one of the active ingredients of Psoralea corylifolia Linn,
has anti-inflammatory properties. We attempted to investigate the inhibitory effects of IPRN …

[HTML][HTML] Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction …

YH Lai, YF Chiang, KC Huang, HY Chen, M Ali… - Biomedicine & …, 2023 - Elsevier
Asthma is a chronic inflammatory disease that has been associated with insufficient
vegetable intake. Allyl Isothiocyanate (AITC) is a natural isothiocyanate found in cruciferous …

The role of macrophage migration inhibitory factor (MIF) in asthmatic airway remodeling

R Li, F Wang, J Wei, Y Lin, G Tang… - Allergy, asthma & …, 2020 - pmc.ncbi.nlm.nih.gov
Purpose Recent studies have demonstrated that macrophage migration inhibitory factor
(MIF) is of importance in asthmatic inflammation. The role of MIF in modulating airway …

[HTML][HTML] Revealing the regulation of allergic asthma airway epithelial cell inflammation by STEAP4 targeting MIF through machine learning algorithms and single-cell …

L Qiao, S Li, J Liu, H Duan, X Jiang - Frontiers in Molecular …, 2024 - frontiersin.org
Asthma comprises one of the most common chronic inflammatory conditions, yet still lacks
effective diagnostic markers and treatment targets. To gain deeper insights, we …

MIF is essential to the establishment of house dust mite‐induced airway inflammation and tissue remodeling in mice

L Lintomen, LM Kluppel, JZ Kitoko… - European Journal of …, 2023 - Wiley Online Library
Macrophage migration inhibitory factor (MIF) is present in high amounts in the BALF and
serum of asthmatic patients, contributing to the pathogenesis of experimental asthma …

Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real‐World Database

YC Lu, CW Yang, YH Lin, JY Hsueh… - Evidence‐Based …, 2020 - Wiley Online Library
Background and Purpose. Allergic rhinitis (AR) is a highly prevalent disease, and Chinese
herbal medicine (CHM) is commonly used for treating AR. This study aims to demonstrate …