Lens arises from ectoderm situated next to the optic vesicles. By thickening and
invaginating, the ectoderm forms the lens vesicle. Growth factors are key regulators of cell …

This review gives a brief account of the main processes of lens development, including
induction, morphogenesis, differentiation and growth. It describes what is known about the …

During the development of the anterior segment of the eye, neural crest mesenchyme cells
migrate between the lens and the corneal epithelium. These cells contribute to the structures …

The vertebrate lens provides an excellent model to study the mechanisms that regulate
terminal differentiation. Although fibroblast growth factors (FGFs) are thought to be important …

Since the days of Hans Spemann, the ocular lens has served as one of the most important
developmental systems for elucidating fundamental processes of induction and …

Growth factors play key roles in influencing cell fate and behaviour during development. The
epithelial cells and fibre cells that arise from the lens vesicle during lens morphogenesis are …

Fibroblast growth factors (FGFs), such as FGF-1, have been shown to induce differentiation
of lens epithelial cells both in tissue culture and in transgenic mice. In the present study …

CREB-2 (also called ATF4, TAXREB67, or C/ATF) is an evolutionarily conserved member of
the CREB/ATF family of basic-leucine zipper transcription factors. CREB-2 is expressed …

Several families of growth factors have been identified as regulators of cell fate in the
developing lens. Members of the fibroblast growth factor family are potent inducers of lens …

Cataract, or opacification of the lens of the eye, is the commonest cause of visual impairment
world-wide. It is only treatable at present by surgical removal. Recent advances in our …