Herein, we present an undirected para-selective two-step C–H alkylation of complex arenes
useful for late-stage functionalization. The combination of a site-selective C–H …

Positron emission tomography (PET) plays key roles in drug discovery and development, as
well as medical imaging. However, there is a dearth of efficient and simple radiolabeling …

A form independent activation of zinc, concomitant generation of organozinc species and
engagement in a Negishi cross‐coupling reaction via mechanochemical methods is …

The Wittig reaction, which is one of the most effective methods for synthesizing alkenes from
carbonyl compounds, generally gives thermodynamically stable E-alkenes, and synthesis of …

Organolithium compounds are amongst the most important organometallic reagents and
frequently used in difficult metallation reactions. However, their direct use in the formation of …

We report the first reductive vinylation of alkyl iodides. The reaction uses a vinyl
thianthrenium salt, a palladium catalyst, and an alkyl zinc intermediate formed in situ to trap …

Herein we present a Ni-catalyzed alkylation of C–SMe with alkyl bromides for the decoration
of heterocyclic frameworks. The protocol, reminiscent to the Liebeskind–Srogl coupling …

Abstract β2-and β3-amino acids are important chiral building blocks for the design of new
pharmaceuticals and peptidomimetics. Here, we report a straightforward regio-and …

A regiodivergent catalytic method for direct conversion of aldehydes to branched or linear
alkyl ketones is described. Rhodium complexes modified by P t Bu2Me catalyze formate …

Grignard-type additions were readily achieved under the mediation of CuI (10 mol%) and
samarium (2 equiv.) by employing various organohalides, eg benzyl, aryl, heterocyclic and …