Linkers for solid phase organic synthesis

IW James - Tetrahedron, 1999 - Elsevier
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[图书][B] Organic synthesis on solid phase: supports, linkers, reactions

FZ Dörwald, FZ Dèorwald - 2002 - Wiley Online Library
Organic Synthesis on Solid Phase | Wiley Online Books Skip to Main Content Wiley Online
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An alkanesulfonamide “safety-catch” linker for solid-phase synthesis

BJ Backes, JA Ellman - The Journal of Organic Chemistry, 1999 - ACS Publications
An alkanesulfonamide “safety-catch” linker has been developed for tethering carboxylic
acids to support. Acylation of the sulfonamide support provides a support-bound N …

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

AM Aronov, S Suresh, FS Buckner… - Proceedings of the …, 1999 - National Acad Sciences
The bloodstream stage of Trypanosoma brucei and probably the intracellular (amastigote)
stage of Trypanosoma cruzi derive all of their energy from glycolysis. Inhibiting glycolytic …

Adenosine Analogues as Selective Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase of Trypanosomatidae via Structure-Based Drug Design

JC Bressi, CLMJ Verlinde, AM Aronov… - Journal of medicinal …, 2001 - ACS Publications
In our continuation of the structure-based design of anti-trypanosomatid drugs, parasite-
selective adenosine analogues were identified as low micromolar inhibitors of …

Solid-Phase Synthesis of Oligosaccharides and On-Resin Quantitative Monitoring Using Gated Decoupling 13C NMR

T Kanemitsu, CH Wong, O Kanie - Journal of the American …, 2002 - ACS Publications
A general strategy for solid-phase oligosaccharide synthesis capable of nondestructive
quantitative monitoring has been developed. The synthesis was carried out on TentaGel …

The Reversed Kenner Linker:  A New Safety-Catch Linker for the Preparation of N-Alkyl Sulfonamides

D Maclean, R Hale, M Chen - Organic Letters, 2001 - ACS Publications
A new strategy for the solid-phase synthesis of sulfonamides is described. The Kenner
safety-catch strategy has been modified such that the carboxylic acid component remains …

Microwave-assisted acylation of amines, alcohols, and phenols by the use of solid-supported reagents (SSRs)

E Petricci, C Mugnaini, M Radi, F Corelli… - The Journal of Organic …, 2004 - ACS Publications
A microwave-assisted synthesis of solid-supported reagents for the acylation of amines has
been developed, and the same methodology has been successfully applied to the …

Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors

HS Overkleeft, PR Bos, BG Hekking, EJ Gordon… - Tetrahedron …, 2000 - Elsevier
Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome
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Synthesis of novel exocyclic amino nucleosides by parallel solid-phase combinatorial strategy

CV Varaprasad, Q Habib, DY Li, J Huang, JW Abt… - Tetrahedron, 2003 - Elsevier
A versatile parallel solid-phase combinatorial strategy was developed for the synthesis of
large nucleoside libraries. Twelve libraries L1-12 of 1152 novel exocyclic triazinylamino …