Triple‐negative breast cancer (TNBC) is a subgroup of 15%‐20% of diagnosed breast
cancer patients. It is generally considered to be the most difficult breast cancer subtype to …

Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased
risk of developing several malignancies. The biological and pathogenic importance of Hh …

The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate
decisions in both embryonic and adult life. Several aspects of stem cell maintenance are …

The T-cell inhibitory molecule PD-L1 is expressed on a fraction of breast cancer cells. The
distribution of PD-L1 on the different subpopulations of breast cancer cells is not well …

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control
cell fate in many developmental and adult tissue contexts. Notch signalling continues to be …

Liver cholestatic diseases, which stem from diverse etiologies, result in liver toxicity and
fibrosis and may progress to cirrhosis and liver failure. We show that CCN1 (also known as …

Mycosis fungoides (MF) is the most common cutaneous T‐cell lymphoma (CTCL). Causative
genetic alterations in MF are unknown. The low recurrence of pathogenic small‐scale …

The Notch family is a highly conserved gene group that regulates cell‐cell interaction,
embryogenesis, and tissue commitment. This review article focuses on the third Notch family …

The Notch signaling pathway consists of transmembrane ligands and receptors that can
interact both within the same cell (cis) and across cell boundaries (trans). Previous work has …

Notch is a highly conserved signaling system that allows neighboring cells to communicate,
thereby controlling their differentiation, proliferation and apoptosis, with the outcome of its …